Central pontine myelinolysis following 'slow' correction of hyponatremia

Clin Neurol Neurosurg. 1995 Nov;97(4):340-3. doi: 10.1016/0303-8467(95)00060-w.


Two patients with central pontine myelinolysis are described for the peculiar mode of development. Both patients were in chronic renal failure and admitted in a stuporous state due to hyponatremia. Both developed central pontine myelinolysis during the hospital stay following slow and judicious correction of hyponatremia. The role of chronicity of hyponatremia prior to its correction, in the genesis of central pontine myelinolysis, particularly in the patients who have chronic debilitating illness, septicemia or malnutrition, is highlighted.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diet Therapy / adverse effects*
  • Humans
  • Hyponatremia / etiology
  • Hyponatremia / therapy*
  • Kidney Failure, Chronic / complications
  • Magnetic Resonance Imaging
  • Male
  • Myelinolysis, Central Pontine / diagnosis
  • Myelinolysis, Central Pontine / etiology*
  • Myelinolysis, Central Pontine / physiopathology*
  • Pons / physiopathology*
  • Sodium / blood


  • Sodium