Elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans in occupationally exposed persons

J Toxicol Environ Health. 1996 Mar;47(4):363-78. doi: 10.1080/009841096161708.


The elimination of 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) was investigated in a group of n = 43 exposed workers with 2 blood measurements and n = 5 workers with 3 measurements. Under the assumption of a one-compartment, first-order kinetic model the median half-life for 2,3,7,8-TCDD was 7.2 yr, while for the other dioxins the estimates were between 3.7 yr for 1,2,3,4,6,7,8-HpCDD (hepta-chlorinated) and 15.7 yr for 1,2,3,7,8-PCDD (penta-chlorinated). For the furans median half-lives between 3.0 yr for 1,2,3,4,6,7,8-HpCDF and 19.6 yr for 2,3,4,7,8-PCDF were observed. There was no indication for a deviation from a first-order kinetic. Increasing age and percent body fat were associated with increasing half-life for most of the congeners. Smokers in general had a faster decay than non- and ex-smokers. In summary, the higher chlorinated PCDD/F like TCDD appear to be highly persistent in humans with half-lives ranging between 4 and 12 yr.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / chemistry
  • Adult
  • Benzofurans / blood
  • Benzofurans / pharmacokinetics*
  • Cholesterol / blood
  • Data Interpretation, Statistical
  • Dioxins / blood
  • Dioxins / pharmacokinetics*
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Models, Statistical
  • Occupational Exposure*
  • Polychlorinated Dibenzodioxins / analogs & derivatives
  • Polychlorinated Dibenzodioxins / blood
  • Polychlorinated Dibenzodioxins / pharmacokinetics*
  • Smoking
  • Time Factors


  • Benzofurans
  • Dioxins
  • Polychlorinated Dibenzodioxins
  • Cholesterol