Population dynamics of immune responses to persistent viruses

Science. 1996 Apr 5;272(5258):74-9. doi: 10.1126/science.272.5258.74.

Abstract

Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / immunology
  • Antigenic Variation
  • Antigens, Viral / immunology
  • Cytokines / immunology
  • Cytotoxicity, Immunologic
  • Epitopes / immunology
  • Genetic Variation
  • HIV Infections / immunology
  • HIV Infections / virology
  • HIV-1 / immunology
  • HIV-1 / physiology
  • HTLV-I Infections / immunology
  • HTLV-I Infections / virology
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / immunology
  • Human T-lymphotropic virus 1 / physiology
  • Humans
  • Models, Biological*
  • Mutation
  • Population Dynamics
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Diseases / immunology*
  • Virus Diseases / virology
  • Virus Physiological Phenomena
  • Virus Replication
  • Viruses / genetics
  • Viruses / immunology*

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Cytokines
  • Epitopes