MR imaging in solvent-induced chronic toxic encephalopathy

Acta Radiol. 1996 Mar;37(2):177-9. doi: 10.1177/02841851960371P136.


Purpose: To use MR to examine patients with CNS symptoms indicating +chronic intoxication.

Material and methods: Thirty-two subjects exposed to industrial solvents for 5 to 28 years and 40 age-matched, healthy controls were examined.

Results: All patients showed decreased signal in the basal ganglia on T2-weighted images. In 11 of the patients the white matter showed diffuse hyperintensity with loss of the grey-white matter discrimination and with distinct periventricular hyperintensities in 5 of the patients. The controls had no pathological changes in the brain.

Conclusion: Although the relatively small number of patients may obscure the significance, findings observed on T2-weighted images were patchy periventricular hyperintensities and hypointensities in the basal ganglia. Fast spin-echo is a good technique with fast acquisition of images with true spin-echo contrast features.

MeSH terms

  • Adult
  • Basal Ganglia / pathology
  • Brain Diseases / chemically induced*
  • Brain Diseases / diagnosis*
  • Chronic Disease
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / diagnosis*
  • Occupational Exposure
  • Poisoning / diagnosis
  • Solvents / toxicity*


  • Solvents