Carotid plaque regression on oestrogen replacement: a pilot study

Eur J Vasc Endovasc Surg. 1996 Apr;11(3):347-8. doi: 10.1016/s1078-5884(96)80083-9.

Abstract

Objective: To investigate the effect of unopposed oestrogen on atheromatous carotid plaques.

Subjects: Seventeen postmenopausal women with known carotid disease.

Methods: Carotid intimal thickness and plaque length and thickness were measured prior to and following 3 and 6 months of treatment, using Duplex ultrasound. A total of 22 plaques were followed up.

Results: There was a reduction in plaque length after 3 (-8.14%, p = 0.001) and 6 months (-28%, p = 0.001) of treatment. The reduction in plaque thickness (-18%, p = 0.004) was significant after 6 months of treatment. Reductions in intimal thickness were not statistically significant.

Conclusion: Our results suggest that oestrogen replacement is associated with significant plaque regression.

MeSH terms

  • Aged
  • Arteriosclerosis / diagnostic imaging
  • Arteriosclerosis / drug therapy*
  • Carotid Arteries / diagnostic imaging
  • Carotid Artery Diseases / diagnostic imaging
  • Carotid Artery Diseases / drug therapy*
  • Drug Combinations
  • Estradiol / administration & dosage*
  • Estriol / administration & dosage*
  • Estrogen Replacement Therapy*
  • Estrone / administration & dosage*
  • Female
  • Humans
  • Middle Aged
  • Pilot Projects
  • Postmenopause
  • Ultrasonography

Substances

  • Drug Combinations
  • Estrone
  • Estradiol
  • hormonin
  • Estriol