Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia

Neurosci Res. 1995 Nov;23(4):361-4. doi: 10.1016/0168-0102(95)00965-V.


To evaluate the responses to insulin-induced hypoglycemia of neurons in vivo, we studied Fos protein induction in the brain by means of immunohistochemistry. The induction of Fos protein was maximum after the first injection of insulin for 3 h. This induction was found in the parvocellular division of paraventricular nucleus (PVN), the periventricular, dorsomedial and arcuate nuclei and the lateral hypothalamic area of the hypothalamus. These findings show the activation of specific subsets of neurons in areas of the hypothalamus following hypoglycemic stimulation.

MeSH terms

  • Animals
  • Antibody Specificity
  • Gene Expression / physiology
  • Glucose / physiology
  • Hypoglycemia / chemically induced
  • Hypoglycemia / physiopathology*
  • Hypothalamus / chemistry*
  • Hypothalamus / physiology
  • Immunohistochemistry
  • Insulin / adverse effects
  • Male
  • Neurons / chemistry
  • Neurons / immunology
  • Proto-Oncogene Proteins c-fos / analysis
  • Proto-Oncogene Proteins c-fos / genetics*
  • Proto-Oncogene Proteins c-fos / immunology
  • Rats
  • Rats, Wistar


  • Insulin
  • Proto-Oncogene Proteins c-fos
  • Glucose