Independent modes of natural killing distinguished in mice lacking Lag3

Science. 1996 Apr 19;272(5260):405-8. doi: 10.1126/science.272.5260.405.


The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD*
  • B-Lymphocytes / immunology
  • Base Sequence
  • Cytotoxicity, Immunologic*
  • Female
  • Histocompatibility Antigens Class I / immunology
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation Gene 3 Protein
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • T-Lymphocytes / immunology
  • Tumor Cells, Cultured
  • beta 2-Microglobulin / deficiency
  • beta 2-Microglobulin / physiology


  • Antigens, CD
  • Histocompatibility Antigens Class I
  • Membrane Proteins
  • beta 2-Microglobulin
  • Lymphocyte Activation Gene 3 Protein
  • Lag3 protein, mouse

Associated data

  • GENBANK/X98113