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, 102 (1-2), 73-6

Mxi1 Tumor Suppressor Gene Is Not Mutated in Primary Pancreatic Adenocarcinoma

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Mxi1 Tumor Suppressor Gene Is Not Mutated in Primary Pancreatic Adenocarcinoma

D Bartsch et al. Cancer Lett.

Abstract

Amplification of the c-myc oncogene occurs in a variety of solid tumors, including pancreatic adenocarcinomas. The MXI1 gene, located at 10q24-q25, may serve to negatively regulate c-myc oncogene activity, and potentially has tumor suppressor function. As such, altered MXI1 function might contribute to tumorigenesis. We examined 40 primary human pancreatic adenocarcinomas for MXI1 mutations. Single-strand conformation variant analysis and direct sequencing of the variants revealed a MXI1 polymorphism in 1 of 40 tumors. No MXI1 mutations were identified. Southern blot analyses did not reveal any gross rearrangements of MXI1. These results suggest that MXI1 is unlikely to play a role in human pancreatic adenocarcinoma tumorigenesis.

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