Congenital bilateral perisylvian syndrome in a monozygotic twin with intra-uterine death of the co-twin

Dev Med Child Neurol. 1996 Feb;38(2):166-70. doi: 10.1111/j.1469-8749.1996.tb12088.x.


Congenital bilateral perisylvian syndrome was diagnosed in a two-year- old boy with signs of pseudobulbar and diplegic cerebral palsy presenting on MRI a polymicrogyric appearance of the perisylvian regions. He was born from a monochorionic bi-amniotic twin pregnancy complicated by twin-twin transfusion syndrome and death of the co-twin between the 16th and 18th weeks of gestation. Ventricular enlargement and hepatic hyperechogenic lesions were seen during his sonographic intra-uterine follow-up. The authors suggest that ischaemic injury occurred in this patient as a consequence of acute haemodynamic changes induced by the death of his co-twin.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Aqueduct / abnormalities*
  • Cerebral Palsy / congenital
  • Cerebral Palsy / diagnosis*
  • Child, Preschool
  • Female
  • Fetal Death / complications*
  • Fetofetal Transfusion / complications*
  • Humans
  • Male
  • Paralysis / congenital
  • Paralysis / diagnosis*
  • Pregnancy
  • Syndrome
  • Twins, Monozygotic*