The Epidemiology of Chlamydia Trachomatis Within a Sexually Transmitted Diseases Core Group

J Infect Dis. 1996 Apr;173(4):950-6. doi: 10.1093/infdis/173.4.950.

Abstract

Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P=.007), gonococcal infection (P=.002), human immunodeficiency virus (HIV) seropositivity (P=.003), HIV seroconversion (P=.001), and duration of prostitution (P=.002). Eighteen different C. trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P=.005). Seventeen of 19 reinfections > or = 6 months apart were with different C. trachomatis omp1 genotypes. Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P=.001) and an increased risk of reinfection (P=.008). Overall, the data demonstrate significant fluctuations in the genotype composition of the C. trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Outer Membrane Proteins / genetics*
  • Base Sequence
  • Chlamydia Infections / epidemiology*
  • Chlamydia trachomatis / immunology*
  • Chlamydia trachomatis / pathogenicity
  • DNA, Bacterial / analysis
  • Female
  • Genes, Bacterial
  • HIV Seropositivity / complications*
  • Humans
  • Longitudinal Studies
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Prospective Studies
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sex Work
  • Sexually Transmitted Diseases / epidemiology*
  • Time Factors

Substances

  • Bacterial Outer Membrane Proteins
  • DNA, Bacterial