Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA

Biochim Biophys Acta. 1996 Feb 7;1305(1-2):15-8. doi: 10.1016/0167-4781(95)00205-7.

Abstract

Cloned cDNA encoding a putative member of GABA receptor rho-subunit class was isolated from rat-retina-mRNA-derived libraries. The cDNA encodes a signal peptide of 21 amino acids followed by the mature rho 3 subunit sequence of 443 amino acids. The proposed amino acid sequence exhibits 63 and 61% homology to the previously-reported human rho 1 and rat rho 2 sequences, respectively. Northern blot analysis demonstrated the expression of mRNA for rho 3 subunit in retina.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Gene Library
  • Humans
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Sorting Signals / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats
  • Receptors, GABA / chemistry
  • Receptors, GABA / genetics*
  • Receptors, GABA-A
  • Retina / metabolism
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • DNA, Complementary
  • Gabrr3 protein, rat
  • Protein Sorting Signals
  • RNA, Messenger
  • Receptors, GABA
  • Receptors, GABA-A

Associated data

  • GENBANK/D50671