Cure for a crisis?

Nat Struct Biol. 1996 Mar;3(3):218-21. doi: 10.1038/nsb0396-218.

Abstract

The first look at the three-dimensional structure of an essential penicillin binding protein from a human pathogen, and its complex with a beta-lactam antibiotic provides hope for the future design of improved antibiotics.

Publication types

  • Comment
  • News

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins*
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism
  • Cefuroxime / chemistry
  • Cefuroxime / metabolism*
  • Cephalosporins / chemistry
  • Cephalosporins / metabolism
  • Crystallography, X-Ray
  • Hexosyltransferases*
  • Humans
  • Molecular Sequence Data
  • Muramoylpentapeptide Carboxypeptidase / chemistry*
  • Muramoylpentapeptide Carboxypeptidase / metabolism
  • Penicillin-Binding Proteins
  • Penicillins / metabolism
  • Peptidoglycan / chemistry
  • Peptidoglycan / metabolism
  • Peptidyl Transferases*
  • Streptococcus pneumoniae / metabolism

Substances

  • Bacterial Proteins
  • Carrier Proteins
  • Cephalosporins
  • Penicillin-Binding Proteins
  • Penicillins
  • Peptidoglycan
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase
  • Cefuroxime