Trisomy 16 fetus surviving into the second trimester

Prenat Diagn. 1995 Nov;15(11):1078-81. doi: 10.1002/pd.1970151115.


A 27-year-old gravida 4, para 3 was found to have anhydramnios at 14 weeks' gestation following a size/date discrepancy noted at her routine prenatal visit. A detailed ultrasound revealed multiple fetal anomalies including congenital heart defect, chest hypoplasia, and bilateral dysplastic kidneys. Karyotype revealed trisomy 16 in 15/15 cells from a tissue specimen obtained from the fetal cord insertion site following elective pregnancy termination.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging
  • Abnormalities, Multiple / genetics
  • Abortion, Induced
  • Adult
  • Chromosomes, Human, Pair 16*
  • Female
  • Humans
  • Karyotyping
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Trimester, Second
  • Trisomy*
  • Ultrasonography, Prenatal*
  • Wolff-Parkinson-White Syndrome