Aspergillosis of the sphenoid sinus: presentation as a pituitary mass and postoperative gallium-67 imaging

Surg Neurol. 1996 Apr;45(4):354-8. doi: 10.1016/0090-3019(95)00484-x.


Invasive aspergillosis of the paranasal sinuses is an uncommon, but well-recognized, form of fungal infection. We describe an elderly female patient with invasive aspergillosis of the sphenoid sinus and associated osteomyelitis of the skull base, with clinical presentation as a pituitary mass. Postoperative gallium scan showed intense uptake in the sphenoid sinus, which resolved after treatment with amphotericin-B. This case demonstrates some of the pathologic and clinical features of invasive aspergillosis and suggests a potential role for gallium-67 imagining in monitoring clinical response to therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amphotericin B / therapeutic use
  • Aspergillosis / diagnosis*
  • Aspergillosis / drug therapy
  • Aspergillosis / pathology
  • Aspergillosis / surgery
  • Aspergillus / isolation & purification
  • Diagnosis, Differential
  • Female
  • Gallium Radioisotopes*
  • Humans
  • Magnetic Resonance Imaging*
  • Pituitary Gland / pathology
  • Pituitary Neoplasms / diagnosis*
  • Sphenoid Sinusitis / diagnosis*
  • Sphenoid Sinusitis / drug therapy
  • Sphenoid Sinusitis / surgery


  • Gallium Radioisotopes
  • Amphotericin B