Spontaneous regression of a histologically proven hepatocellular carcinoma was observed in a 62-yr-old male Slovenian patient with HBsAg-positive liver cirrhosis and a remarkable family history of hepatocellular carcinoma. After 3 months of persistent high fever, the patient's condition improved, and liver resection was performed. Histological examination of resected liver specimen revealed necrosis with pseudocapsular lining and no malignant cells. The patient is alive, without evidence of recurrence, 8 yr after the diagnosis was established.