The role of polysialic acid in migration of olfactory bulb interneuron precursors in the subventricular zone

Neuron. 1996 Apr;16(4):735-43. doi: 10.1016/s0896-6273(00)80094-x.


Transplantation studies have been used to show that tangential migration of olfactory bulb interneuron precursors is retarded in NCAM-mutant mice, and that this defect reflects loss of NCAM polysialic acid (PSA). In contrast, radial migration of cells within the bulb did not require PSA. Reciprocal transplantations between wild-type and mutant mice have revealed that the mutation affects the in vivo migration environment in the subventricular zone, and not movement of individual cells. However, in vitro migration of the cells into a PSA-negative collagen matrix environment was also PSA dependent. The surprisingly similar results obtained in the in vivo and in vitro environments is consistent with the observation that migration of subventricular cells occurs as streams of closely apposed cells in which the PSA-positive cells appear to serve as their own migration substrate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain / cytology
  • Cell Movement / physiology*
  • Collagen
  • Culture Media
  • Culture Techniques
  • Fluorescent Antibody Technique, Indirect
  • Interneurons / cytology*
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Neural Cell Adhesion Molecules / chemistry
  • Neural Cell Adhesion Molecules / genetics
  • Olfactory Bulb / cytology*
  • Olfactory Bulb / transplantation
  • Sialic Acids / genetics
  • Sialic Acids / physiology*
  • Stem Cells / cytology*


  • Culture Media
  • Neural Cell Adhesion Molecules
  • Sialic Acids
  • polysialic acid
  • Collagen