Ca2+ signaling requirements for long-term depression in the hippocampus

Neuron. 1996 Apr;16(4):825-33. doi: 10.1016/s0896-6273(00)80102-6.


It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD) and long-term potentiation (LTP) can be elicited and are Ca2+ dependent. Brief tetanic stimulation, which normally generated LTP, could induce LTD when Ca2+ entry via NMDA receptors was limited either by moderate concentrations of D-APV or by voltage clamping cells at negative membrane potentials. Repetitive activation of voltage-dependent Ca2+ channels in the absence of afferent stimulation could also elicit an LTD that was Ca2+ dependent and was occluded by prior generation of homosynaptic LTD using prolonged low evidence that the minimal requirements for inducing LTD involve simply a transient influx of Ca2+ into the postsynaptic cell, via either NMDA receptors or voltage-dependent Ca2+ channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Calcium / metabolism*
  • Chelating Agents / pharmacology
  • Egtazic Acid / analogs & derivatives
  • Egtazic Acid / pharmacology
  • Electrophysiology
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Long-Term Potentiation / physiology
  • Neuronal Plasticity / physiology*
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Signal Transduction / physiology*
  • Synapses / physiology


  • Chelating Agents
  • Receptors, N-Methyl-D-Aspartate
  • Egtazic Acid
  • 2-Amino-5-phosphonovalerate
  • 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
  • Calcium