Starting the cell cycle: what's the point?

Curr Opin Cell Biol. 1995 Dec;7(6):790-7. doi: 10.1016/0955-0674(95)80062-x.


Early work on regulation of the budding yeast cell cycle defined a critical regulatory step called 'Start', considered to represent cell cycle commitment. Recent work has defined the probable molecular basis of Start to be activation of Cln-Cdc28 protein kinase complexes. Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Time Factors
  • Yeasts / cytology