Marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

Cell. 1996 Feb 9;84(3):411-9. doi: 10.1016/s0092-8674(00)81286-6.

Abstract

We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • DNA-Binding Proteins / genetics*
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins
  • Female
  • Genes, Insect
  • Janus Kinases
  • Male
  • Models, Genetic
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Protein-Tyrosine Kinases / genetics*
  • Sequence Homology, Amino Acid
  • Signal Transduction / genetics
  • Suppression, Genetic
  • Trans-Activators / genetics*
  • Transcription Factors

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Trans-Activators
  • Transcription Factors
  • DNA
  • Protein-Tyrosine Kinases
  • Janus Kinases
  • hop protein, Drosophila

Associated data

  • GENBANK/U40070