A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Nature. 1996 May 2;381(6577):86-9. doi: 10.1038/381086a0.


We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, Affinity
  • DNA Repair*
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Protein Binding
  • RNA Polymerase II / metabolism*
  • Recombinant Proteins / metabolism
  • Transcription Factor TFIIH
  • Transcription Factors / metabolism*
  • Transcription Factors, TFII*
  • Transcription, Genetic


  • Recombinant Proteins
  • Transcription Factors
  • Transcription Factors, TFII
  • Transcription Factor TFIIH
  • RNA Polymerase II

Associated data

  • GENBANK/U52960