The genetics of pain and pain inhibition

Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3048-55. doi: 10.1073/pnas.93.7.3048.


The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we feel demonstrates the continuing usefulness of classical genetic approaches, especially when used in combination with newly available molecular genetic techniques.

Publication types

  • Review

MeSH terms

  • Analgesia
  • Animals
  • Crosses, Genetic
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 Enzyme System / genetics
  • Humans
  • Los Angeles
  • Mice
  • Mice, Inbred Strains
  • Mixed Function Oxygenases / genetics
  • Models, Genetic*
  • Pain / genetics*
  • Pain / physiopathology*
  • Pain / prevention & control
  • Perception
  • Point Mutation
  • Poland
  • Recombination, Genetic


  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Cytochrome P-450 CYP2D6