Hyaluronan-binding properties of human serum hemopexin

FEBS Lett. 1996 Mar 25;383(1-2):72-4. doi: 10.1016/0014-5793(96)00225-6.

Abstract

Hemopexin, the heme-binding serum glycoprotein, exhibits a complex electrophoretic pattern on two-dimensional immunoelectrophoresis on agarose gels into which hyaluronic acid is incorporated in the first and monospecific anti-hemopexin in the second dimension. This heterogeneity reflects a range of interactions of hemopexin isoforms with hyaluronic acid. Electrophoretic patterns of individual human sera greatly differ in their contents of hyaluronan-interacting hemopexin species. Hemopexin itself has no hyaluronidase activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Electrophoresis, Gel, Two-Dimensional
  • Electrophoresis, Polyacrylamide Gel
  • Hemopexin / chemistry
  • Hemopexin / metabolism*
  • Humans
  • Hyaluronic Acid / metabolism*
  • Hyaluronoglucosaminidase / metabolism
  • Immunoelectrophoresis

Substances

  • Hyaluronic Acid
  • Hemopexin
  • Hyaluronoglucosaminidase