Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid

Gastroenterology. 1996 May;110(5):1379-85. doi: 10.1053/gast.1996.v110.pm8613041.


Background & aims: The combination of duodenal lipid and gastric distention induces meal-like fullness followed by nausea in healthy subjects. The aim of this study was to assess the role of cholecystokinin (CCK) A receptors in these changes using a CCK-A antagonist loxiglumide.

Methods: Twelve healthy subjects were studied on four occasions, during which either 0.9% saline or 20% Intralipid was infused intraduodenally on two occasions each (1 mL/min) while the proximal stomach was distended with air (100 mL/min). During each duodenal infusion, subjects received intravenous loxiglumide (10 on 1 day and placebo on the other. Intragastric pressure changes were recorded, and the subjects reported gastric sensations (fullness, nausea).

Results: Loxiglumide did not influence gastric motility or sensitivity during duodenal saline infusion. Duodenal lipid reduced gastric tonic and phasic pressure activity during distensions and induced meal-like fullness and nausea; sensations were reported at similar volumes but lower intragastric pressures (P < 0.001 vs. saline). Loxiglumide partially restored gastric tonic and phasic activity during lipid infusion, reduced the occurrence of meal-like fullness and nausea, and increased the pressures at which sensations were reported (P < 0.001 vs. placebo).

Conclusions: CCK-A receptors are involved in the induction of meal-like fullness and nausea associated with intraduodenal lipid and gastric distention.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Chi-Square Distribution
  • Duodenum / drug effects*
  • Fat Emulsions, Intravenous / pharmacology*
  • Female
  • Gastric Dilatation / metabolism
  • Gastric Dilatation / physiopathology*
  • Gastric Mucosa / metabolism
  • Gastrointestinal Motility*
  • Hormone Antagonists / pharmacology
  • Humans
  • Male
  • Nausea / physiopathology
  • Pressure
  • Proglumide / analogs & derivatives
  • Proglumide / pharmacology
  • Receptors, Cholecystokinin / antagonists & inhibitors
  • Receptors, Cholecystokinin / physiology*
  • Sensation*
  • Stomach / physiopathology*


  • Fat Emulsions, Intravenous
  • Hormone Antagonists
  • Receptors, Cholecystokinin
  • loxiglumide
  • Proglumide