Sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70

Jpn J Cancer Res. 1996 Mar;87(3):310-6. doi: 10.1111/j.1349-7006.1996.tb00222.x.


The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use*
  • Back
  • Carcinoma / drug therapy*
  • Chemical Phenomena
  • Chemistry, Physical
  • Colonic Neoplasms / drug therapy*
  • Drug Screening Assays, Antitumor
  • Gallium / pharmacokinetics
  • Gallium / therapeutic use
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neoplasm Transplantation
  • Porphyrins / pharmacokinetics
  • Porphyrins / therapeutic use*
  • Ultrasonic Therapy*


  • Antineoplastic Agents
  • Porphyrins
  • ATX 70
  • Gallium