Reduced mercury excretion with feces in germfree mice after oral administration of methyl mercury chloride

Bull Environ Contam Toxicol. 1977 May;17(5):528-33. doi: 10.1007/BF01685974.

Abstract

When methyl mercury chloride was administered orally the amount of mercury excretion with feces of germfree mice was noticeably lower than that of the control mice. Germfree mice excreted 24 percent of the administered mercury within 10 days of administration while the control mice excreted 46 percent. Mercury retention in the organs of germfree mice was slightly higher than in the control mice. These results suggest that the existence of microorganisms in animal intestines are concerned with mercury excretion in the animal body.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Feces / analysis*
  • Female
  • Germ-Free Life
  • Intestinal Absorption
  • Kidney / analysis
  • Liver / analysis
  • Mercury / metabolism*
  • Mercury / urine
  • Methylmercury Compounds / pharmacology*
  • Mice
  • Mice, Inbred ICR
  • Spleen / analysis
  • Time Factors

Substances

  • Methylmercury Compounds
  • Mercury