Hyperprolactinemia in systemic lupus erythematosus?

Scand J Rheumatol. 1996;25(2):97-102. doi: 10.3109/03009749609069215.


The objective of this project was to determine the prevalence of hyperprolactinemia (HPRL) in systemic lupus erythematosus (SLE) and to evaluate the role of prolactin (PRL) as a disease-activity marker. We determined PRL in a cohort of 182 patients with SLE. Basal prolactin levels and clinical data (disease-activity index, sero-activity, medications) were analyzed in all patients. The findings show only mildly elevated PRL levels in four SLE-patients and normaprolactinemia in 98% (n = 178), without any association with disease activity. Our results differ from previous studies. HPRL appears not to be prevalent in SLE, nor to be associated with disease activity.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Sedimentation
  • Cohort Studies
  • Female
  • Humans
  • Hyperprolactinemia / blood
  • Hyperprolactinemia / epidemiology*
  • Hyperprolactinemia / etiology
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / complications*
  • Male
  • Middle Aged
  • Prevalence
  • Prolactin / blood*
  • Severity of Illness Index


  • Prolactin