Antitumor effect of TNP-470 on glial tumors transplanted in rats

Anticancer Res. Jan-Feb 1996;16(1):71-6.

Abstract

Anti-angiogenic agents were be clinically useful for the therapy of solid tumors, as the growth and proliferation of tumors require neovascularization. Previous reports have been made on the antitumor effect of TNP-470, an angiogenic inhibitor, on medulloblastomas implanted subcutaneously into nude mice. The present study was undertaken for the purpose of investigating possible antitumor effects on two model subcutaneous and intracranial tumors transplanted into rats. 9-L gliosarcomas were transplanted into the left femoral region subcutaneously and the left frontal region of Fisher 344 female rats, and the TNP-470 was then administered subcutaneously. The rats were divided into two treatment groups and a control group. TNP-470 resulted in dose-dependent inhibition of 9-L gliosarcoma growth and also prolonged survival in treatment groups. Therefore TNP-470 was considered to be effective for the treatment of malignant brain tumors, although it caused dose-dependent decreases in body weight.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / pharmacology*
  • Body Weight / drug effects
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Cell Division / drug effects
  • Cyclohexanes
  • Endothelium, Vascular / drug effects
  • Female
  • Gliosarcoma / blood supply*
  • Gliosarcoma / drug therapy*
  • Gliosarcoma / pathology
  • Injections, Subcutaneous
  • Neoplasm Transplantation
  • Neovascularization, Pathologic / drug therapy*
  • O-(Chloroacetylcarbamoyl)fumagillol
  • Rats
  • Rats, Inbred F344
  • Sesquiterpenes / pharmacology*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antibiotics, Antineoplastic
  • Cyclohexanes
  • Sesquiterpenes
  • O-(Chloroacetylcarbamoyl)fumagillol