Omeprazole causes delay in gastric emptying of digestible meals

Dig Dis Sci. 1996 Mar;41(3):469-74. doi: 10.1007/BF02282320.


We have studied gastric emptying of a solid, realistic meal (800 cal, 15% protein, 45% fat, 40% carbohydrate) in 21 healthy subjects twice, with and without a four-day pretreatment with 40 mg omeprazole. The last dose of the drug was taken 24 hr before the test, to avoid hypothetical nonsecretory side effects of the drug . Gastric emptying was measured by ultrasound of antral diameters. The results show that basal and maximal postprandial antral cross-sectional areas were the same during the two tests. A greater residual distention of the antrum was present throughout the study after the omeprazole treatment, the difference being significant at time 120 and 240. Omeprazole induced a highly significant delay in gastric emptying [control 199.6 (12.6) vs omeprazole 230.9 (12.7) min, mean (1 SEM); P<0.003]. The delay was not due to a prolonged lag phase, but rather to an effect on the slope of the emptying curve. This study shows that in normal subjects omeprazole delays gastric emptying of a digestible solid meal.

MeSH terms

  • Adult
  • Depression, Chemical
  • Digestion / drug effects*
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Omeprazole / pharmacology*
  • Proton Pump Inhibitors*
  • Proton Pumps / drug effects
  • Reference Values
  • Stomach / diagnostic imaging
  • Time Factors
  • Ultrasonography


  • Proton Pump Inhibitors
  • Proton Pumps
  • Omeprazole