Prostate specimen reevaluation in patients with organ confined prostate cancer and postoperative biological recurrence

J Urol. 1996 Jun;155(6):1981-2.


Purpose: We evaluated whether detectable levels of prostate specific antigen after radical prostatectomy for stage P2 disease are associated with unconfined cancer overlooked at pathological examination.

Materials and methods: Among 129 patients with stages T1 and T2 prostate cancer treated with radical prostatectomy 60 had stage P2 disease. The initial slides from the 7 patients with biological failure were carefully reviewed and, if necessary, the embedded blocks were sectioned every 2 mm.

Results: The disease was upstaged histologically from P2 to P3 in 6 of 7 patients by reinspecting the initial slides (3) and examining new slides (3).

Conclusions: A postoperative detectable prostate specific antigen level in cases of stage P2 cancer reflects the presence of unconfined disease that may be overlooked by histopathological examination.

MeSH terms

  • Aged
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Staging
  • Neoplasm, Residual
  • Prostate / pathology*
  • Prostate-Specific Antigen / blood*
  • Prostatectomy
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery
  • Time Factors


  • Prostate-Specific Antigen