Risk factors for central retinal vein occlusion. The Eye Disease Case-Control Study Group

Arch Ophthalmol. 1996 May;114(5):545-54.


Objective: To identify possible risk factors for central retinal vein occlusion (CRVO).

Design: Between May 1, 1986, and December 31, 1990, 258 patients with CRVO and 1142 controls were identified at five clinical centers. Data were obtained through interviews, clinical examinations, and laboratory analyses of blood specimens.

Results: An increased risk of CRVO was found in persons with systemic hypertension, diabetes mellitus, and open-angle glaucoma. Risk of CRVO decreased with increasing levels of physical activity and increasing levels of alcohol consumption. In women, risk of occlusion decreased with use of postmenopausal estrogens and increased with higher erythrocyte sedimentation rates. Cardiovascular disease, electrocardiographic abnormalities, history of treatment of diabetes mellitus, higher blood glucose levels, lower albumin-globulin ratios, and higher alpha-globulin levels were associated with increased risk only for ischemic CRVO. Systemic hypertension was associated with increased risk for ischemic and nonischemic CRVO, but odds ratios were greater for the ischemic type.

Conclusions: Our results suggest a cardiovascular risk profile for persons with CRVO, in particular, patients with the ischemic type. The findings reinforce recommendations to diagnose and treat systemic hypertension, advise patients to increase physical exercise, and consider use of exogenous estrogens in postmenopausal women.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Sedimentation
  • Case-Control Studies
  • Diabetes Complications
  • Estrogen Replacement Therapy
  • Exercise
  • Female
  • Glaucoma, Open-Angle / complications
  • Humans
  • Hypertension / complications
  • Male
  • Middle Aged
  • Odds Ratio
  • Retinal Vein Occlusion / epidemiology
  • Retinal Vein Occlusion / etiology*
  • Risk Factors
  • United States / epidemiology