Prediction of complications in gamma knife radiosurgery of arteriovenous malformation

Acta Oncol. 1996;35(1):49-55. doi: 10.3109/02841869609098479.


The incidence of complications following radiosurgical treatment of arteriovenous malformations (AVM) is presented. A simple relationship exists between average dose and risk of complications, and on this basis a model is presented that gives a qualitatively correct description of this relationship. The parameters of the model have been determined using a clinical material of 862 AVM treatments to give a quantitatively correct description of the risk of complications. The dose-response curve is described by a double-exponential function. An accurate description of the dose-response curve at high dose levels is shown to be very important in radiosurgery.

MeSH terms

  • Algorithms
  • Brain / radiation effects
  • Dose-Response Relationship, Radiation
  • Follow-Up Studies
  • Humans
  • Incidence
  • Intracranial Arteriovenous Malformations / surgery*
  • Models, Neurological
  • Models, Statistical
  • Probability
  • Radiation Injuries / etiology
  • Radiosurgery / adverse effects*
  • Radiotherapy Planning, Computer-Assisted