Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility-contrast MRI

Magn Reson Med. 1996 Feb;35(2):168-73. doi: 10.1002/mrm.1910350207.


The utility of a noninvasive steady state susceptibility-contrast MRI technique for continuous measurement of relative cerebral blood volume (rCBV) during global transient ischemia and subsequent hyperemia in a feline ischemia model is demonstrated. The measurements were obtained during a 10-min period of occlusion and 1-h period of reperfusion. Maximal hyperemic responses in gray matter, basal ganglia, and white matter (observed at 7,7, and 5 min, respectively) were 1.9 +/- 0.5, 1.8 +/- 0.3, and 1.7 +/- 0.6 times greater than baseline CBV (mean +/- SEM). Thirty to forty minutes after onset of reperfusion, CBV returned to normal. Thereafter, it decreased below baseline, nearing the control level by 1 h after onset of reperfusion. Steady state susceptibility-contrast MRI permits continuous, in vivo mapping of alterations in CBV.

MeSH terms

  • Animals
  • Blood Pressure
  • Blood Volume*
  • Cats
  • Cerebrovascular Circulation*
  • Contrast Media*
  • Dextrans
  • Ferrosoferric Oxide
  • Iron*
  • Ischemic Attack, Transient / physiopathology*
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy
  • Magnetite Nanoparticles
  • Oxides*


  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • ferumoxtran-10
  • Iron
  • Ferrosoferric Oxide