The effect of 25-hydroxy vitamin D3 in the osteomalacia of chronic renal failure

Clin Sci Mol Med. 1977 May;52(5):499-508. doi: 10.1042/cs0520499.


1. Five patients with the osteomalacia of chronic renal failure were given 50--100 nmol of 25-hydroxy vitamin D3 intravenously per day for 24--28 days. 2. In all five patients, during administration of 25-hydroxy vitamin D3 there was a substantial rise in the plasma concentration of 25-hydroxy vitamin D from initially abnormally low values. 3. Significant improvement in bone mineralization, intestinal calcium absorption and muscle strength occurred in the three patients with the greatest rise in plasma 25-hydroxy vitamin D.

MeSH terms

  • Aged
  • Calcification, Physiologic
  • Calcium / metabolism
  • Female
  • Humans
  • Hydroxycholecalciferols / therapeutic use*
  • Kidney Failure, Chronic / complications*
  • Male
  • Middle Aged
  • Osteomalacia / drug therapy*
  • Osteomalacia / etiology
  • Phosphorus / blood


  • Hydroxycholecalciferols
  • Phosphorus
  • Calcium