Pulmonary lymphangioleiomyomatosis: a case report in postmenopausal woman treated with pleurodesis and progesterone (medroxyprogesterone acetate)

Tumori. Jan-Feb 1996;82(1):96-8.

Abstract

The main problem in the treatment of pulmonary lymphangioleiomyomatosis, which frequently occurs in the reproductive age, is the control of chylothorax and disease progression. We herein report a case of a 62-year-old woman who underwent surgery for recurrent chylothorax. Histologic examination of lung and lymph node biopsies demonstrated lymphangioleiomyomatosis. Thirty-six months after tetracycline pleurodesis and high-dose medroxyprogesterone acetate therapy, the disease was stable and cyclothorax effectively controlled. It would therefore appear that hormonal treatment with medroxyprogesterone acetate may be beneficial in postmenopausal women.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Female
  • Humans
  • Lung Neoplasms / therapy*
  • Lymphangioleiomyomatosis / therapy*
  • Medroxyprogesterone Acetate / therapeutic use*
  • Middle Aged
  • Pleurodesis*
  • Postmenopause

Substances

  • Antineoplastic Agents, Hormonal
  • Medroxyprogesterone Acetate