Evidence for sltA1 as a salt-sensitive allele of the arginase gene (agaA) in the ascomycete Aspergillus nidulans

Curr Genet. 1996 Apr;29(5):462-7.


Strains of Aspergillus nidulans carrying the sltA1 mutation, conferring sensitivity to KCl and NaCl, also showed an arginine-sensitive phenotype whereby concentrations of the L-amino acid at or above 10 mM were toxic to growth. Sexual progeny of a cross between a sltA1 mutant and a wild-type strain showed a co-segregation of salt and arginine sensitivity. Similarly, revertants to salt tolerance showed a loss of arginine sensitivity as did sltA1 strains that were transformed with a cosmid carrying the putative sltA1+ wild-type allele. In addition, arginine sensitivity could be relieved by L-ornithine. It is suggested that sltA1 is a salt-sensitive allele of the arginase gene (agaA).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Arginase / genetics*
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • Aspergillus nidulans / drug effects
  • Aspergillus nidulans / enzymology
  • Aspergillus nidulans / genetics*
  • Aspergillus nidulans / growth & development
  • Chlorides / pharmacology*
  • Crosses, Genetic
  • Drug Resistance, Microbial
  • Genes, Fungal*
  • Meiosis
  • Mutagenesis
  • Phenotype
  • Potassium Chloride / pharmacology
  • Protoplasts / drug effects
  • Sodium Chloride / pharmacology
  • Transformation, Genetic


  • Chlorides
  • Sodium Chloride
  • Potassium Chloride
  • Arginine
  • Arginase