Phase 1 trial of intraperitoneal AD-32 in gynecologic malignancies

Gynecol Oncol. 1996 Apr;61(1):90-3. doi: 10.1006/gyno.1996.0102.


AD-32 (N-trifluoroacetyladriamycin-14-valerate), an analogue of doxorubicin, was examined for intraperitoneal (ip) administration in a phase 2 trial involving 25 patients with advanced gynecologic malignancies. At an AD-32 dose of 600 mg/m2, the limiting toxicity was grade 4 neutropenia (64% of patients), while severe abdominal pain was relatively uncommon (12%). Intraperitoneal AD-32 administration was associated with a 200-fold pharmacokinetic advantage for cavity exposure, compared to the systemic compartment. At the 600 mg/m2 dose level, 4 of 9 patients (44%) with ascites experienced control of malignant fluid reaccumulation. Based on the results of this phase 1 trial, further exploration of a possible role for the ip administration of AD-32 in individuals with gynecological malignancies appears indicated, particularly in patients with either small volume residual disease after initial systemic chemotherapy or in those with intractable ascites.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Cell Count / drug effects
  • Dose-Response Relationship, Drug
  • Doxorubicin / administration & dosage
  • Doxorubicin / adverse effects
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / pharmacokinetics
  • Female
  • Genital Neoplasms, Female / drug therapy*
  • Genital Neoplasms, Female / metabolism*
  • Humans
  • Injections, Intraperitoneal
  • Middle Aged
  • Treatment Outcome


  • valrubicin
  • Doxorubicin