Susceptibility of Streptococcus pneumoniae strains isolated in Italy to penicillin and ten other antibiotics

J Antimicrob Chemother. 1995 Nov;36(5):833-7. doi: 10.1093/jac/36.5.833.


The susceptibility of 312 Streptococcus pneumoniae strains isolated during 1993 in Italy has been studied. Overall resistance to penicillin, erythromycin and co-trimoxazole was 5.5, 6 and 18% respectively. The penicillin resistant isolates (nine displaying low- and eight high-level resistance) were further tested against cefotaxime, ceftriaxone, cefepime, cefodizime, ceftazidime, imipenem, meropenem and rifampicin. The low-level penicillin resistant strains were inhibited by all these drugs. Among the eight high-level penicillin resistant pneumococci, four were resistant to one or more cephalosporins. Imipenem and rifampicin remained effective against all isolates. In comparison with other European Mediterranean countries, penicillin resistance is a minor threat at present in Italy.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Italy
  • Microbial Sensitivity Tests
  • Penicillin Resistance
  • Penicillins / pharmacology
  • Streptococcus pneumoniae / drug effects*


  • Anti-Bacterial Agents
  • Penicillins