Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes

J Gen Virol. 1996 Apr;77 ( Pt 4):737-41. doi: 10.1099/0022-1317-77-4-737.

Abstract

DBA/2 mice treated with anti-Mac1 monoclonal antibody (MAb) failed to develop encephalomyocarditis virus (EMCV)-induced diabetes and myocarditis. Virus concentrations and the number of viral RNA-positive cells in the pancreas and heart were significantly reduced in mice treated with anti-Mac1 MAb. Mac1-positive macrophages seem to be involved in EMCV-induced disease and to affect the replication of EMCV in target organs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Viral / immunology
  • Cardiovirus Infections / immunology*
  • Cardiovirus Infections / pathology
  • Cardiovirus Infections / virology
  • Cell Count
  • Cell Line
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 1 / virology*
  • Encephalomyocarditis virus / immunology*
  • Heart / virology
  • Macrophage-1 Antigen / immunology*
  • Macrophages / immunology*
  • Male
  • Mice
  • Mice, Inbred DBA
  • Myocarditis / immunology*
  • Myocarditis / pathology
  • Myocarditis / virology
  • Myocardium / immunology
  • Myocardium / pathology
  • Pancreas / immunology
  • Pancreas / pathology
  • Pancreas / virology
  • RNA, Viral / metabolism
  • Rats
  • Tumor Cells, Cultured

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Macrophage-1 Antigen
  • RNA, Viral