Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections

Radiology. 1996 Mar;198(3):837-43. doi: 10.1148/radiology.198.3.8628880.


Purpose: To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD).

Materials and methods: Standard transaxial section display and 3D-SSP PET image sets obtained after administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose in 39 patients with probable AD (aged 53-82 years; 15 men, 24 women) and 40 subjects without AD (aged 21-78 years; 14 men, 26 women) were randomly interpreted. Receiver operating characteristic (ROC) analysis was performed.

Results: Diagnostic performance was superior with 3D SSP (Az[section]=0.94,Az[3D SSP]=0.99[Az=area under the ROC curve];P=.043). With 3D SSP, diagnosis of AD was equally good in beginners and experts. The sensitivity and specificity in questionable or mild dementia were 94% and 99% with 3D SSP and 79% and 88% with standard transaxial display.

Conclusion: Accuracy of detecting AD was improved in PET with 3D SSP.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnostic imaging*
  • Brain / diagnostic imaging*
  • False Positive Reactions
  • Female
  • Humans
  • Image Processing, Computer-Assisted*
  • Male
  • Middle Aged
  • ROC Curve
  • Sensitivity and Specificity
  • Stereotaxic Techniques*
  • Tomography, Emission-Computed*