The concept of nodal mastopathy is accumulative. Both fibrotic segments and fibroadenomas, cysts, lipomas and other formations with atypical manifestations may serve as a substrate for forming a node. In addition to the clinical method, a diagnostic set should involve mammography that detects the true nature of a formation in 75-91% of cases, traditional sonography providing additional information in cysts in 88% of cases, Doppler sonography suspecting enhanced proliferative processes by the higher blood flow velocity and defining indications for surgical treatment, as well as new puncture bioptic procedures yielding better information materials by 25-30%. The comprehensive assessment of non-specific manifestations of nodal mastopathies from the data obtained by diagnostic techniques enables a more exact preoperative diagnosis to be made.