Immunomodulating and antiviral activities of the imidazoquinoline S-28463

Antiviral Res. 1995 Nov;28(3):253-64. doi: 10.1016/0166-3542(95)00054-p.


Recently, a new class of immunomodulating agents, represented by the molecules imiquimod and R-842, has demonstrated potent antiviral and antitumor activities in animal models. In this study, another representative of this class, S-28463 (4-amino-2-ethoxymethyl-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline- 1- ethanol) was evaluated for its immunomodulating and antiviral activities. S-28463 induced IFN and other cytokines in vivo in mice, rats, monkeys and in vitro in human peripheral blood mononuclear cell cultures. S-28463 showed potent antiviral activity against herpes simplex virus-challenged guinea pigs when given subcutaneously, dermally, or intravaginally 24 h before infection. Antiviral activity in guinea pigs correlated with the induction of serum 2',5'-oligoadenylate synthetase activity. Thus, S-28463, like the other imidazoquinolines, demonstrates potent antiviral and immunomodulating effects in a number of models.

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / biosynthesis
  • Adjuvants, Immunologic / pharmacology
  • Aminoquinolines / pharmacology*
  • Animals
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Cytokines / biosynthesis
  • Female
  • Guinea Pigs
  • Herpes Simplex / prevention & control
  • Herpesvirus 1, Human / drug effects*
  • Interferon Inducers / pharmacology
  • Interferon-alpha / biosynthesis
  • Macaca fascicularis
  • Male
  • Mice
  • Mice, Inbred Strains
  • Rats
  • Rats, Inbred Strains
  • Tumor Necrosis Factor-alpha / biosynthesis


  • Adjuvants, Immunologic
  • Aminoquinolines
  • Antiviral Agents
  • Cytokines
  • Interferon Inducers
  • Interferon-alpha
  • S 28463
  • Tumor Necrosis Factor-alpha
  • 2',5'-Oligoadenylate Synthetase