Coexistence of two antisynthetases in a patient with the antisynthetase syndrome

Arthritis Rheum. 1996 Apr;39(4):692-7. doi: 10.1002/art.1780390424.


We describe the immunologic findings in a patient with the antisynthetase syndrome characterized by prominent arthritis, lung fibrosis, and subclinical myositis. At disease onset and during the followup, this patient's serum showed 2 different subsets of antisynthetase autoantibodies: anti-Jo-1, which reacted with histidyl-transfer RNA (tRNA) synthetase by immunoblot and inhibited its enzymatic function; and anti-0J, which immunoprecipitated the multi-enzyme complex of synthetases, and reacted with lysyl-tRNA synthetase by immunoblot. This is the first report of anti-Jo-1 and another antisynthetase antibody being found together in the same patient.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Antibodies, Anti-Idiotypic / blood*
  • Arthritis / blood
  • Arthritis / immunology*
  • Humans
  • Ligases / immunology*
  • Male
  • Myositis / blood
  • Myositis / immunology*
  • Pulmonary Fibrosis / blood
  • Pulmonary Fibrosis / immunology*
  • Syndrome


  • Antibodies, Anti-Idiotypic
  • Ligases