Cerebral white matter: technical development and clinical applications of effective magnetization transfer (MT) power concepts for high-power, thin-section, quantitative MT examinations

Radiology. 1996 Apr;199(1):219-26. doi: 10.1148/radiology.199.1.8633148.


Purpose: To evaluate white matter disorders with magnetization transfer (MT) techniques.

Materials and methods: In 46 healthy volunteers and 46 clinical patients, MT Z spectra were obtained with various continuous-wave-equivalent MT powers (B1CW) and frequency offsets.

Results: With B1CW of 270 Hz and 4,000-Hz frequency offset, the MT ratio of normal callosal white matter was 59.2% +/- 1.5 (standard deviation), with less than 5% contribution from direct saturation and spin locking. A small statistically significant (P < .01) regional variation in normal white matter was seen. Plaques in MS patients had a broad (or wide) range of MT ratios; normal appearing white matter had a slightly reduced MT ratio. Vasogenic edema had a minimal effect on MT ratio, and radiation necrosis showed prominent reductions in MT ratio.

Conclusion: High MT power techniques can expand the dynamic range of MT ratios, maintain a relatively pure MT effect, and be used effectively in MT imaging to evaluate white matter disorders.

Publication types

  • Comparative Study

MeSH terms

  • Brain / anatomy & histology
  • Brain / pathology*
  • Brain Neoplasms / pathology*
  • Case-Control Studies
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Multiple Sclerosis / pathology*
  • Phantoms, Imaging