Neonatal intracranial ischemia and hemorrhage: diagnosis with US, CT, and MR imaging

Radiology. 1996 Apr;199(1):253-9. doi: 10.1148/radiology.199.1.8633155.


Purpose: To assess the usefulness of ultrasound (US), computed tomography (CT), and magnetic resonance (MR) imaging in the detection of intracranial hemorrhage and ischemia in newborns.

Materials and methods: Seventy-six neonates who underwent US within 72 hours of CT or MR examination were studied. Four observers rated images for the presence of germinal matrix hemorrhage (GMH), intraventricular hemorrhage (IPH), extraaxial hemorrhage, and hypoxic-ischemic encephalopathy.

Results: In 39% of neonates, CT and MR imaging provided greater confidence than US for the diagnosis or exlusion of neonatal ischemia or hemorrhage. Kappa analysis revealed significantly better interobserver agreement with CT than with US for the detection of GMH, IVH, IPH, and cortical infarction or ischemia (P <.005). Interobserver agreement was significantly better with MR imaging than with US for the detection of GMH, IVH, and cortical infarction or ischemia (P < .005).

Conclusion: Sensitivity and interobserver agreement are better with MR imaging and CT than with US for the detection of neonatal cortical ischemia or infarction.

Publication types

  • Comparative Study

MeSH terms

  • Apgar Score
  • Birth Weight
  • Brain / pathology
  • Brain Ischemia / diagnosis*
  • Brain Ischemia / epidemiology
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / epidemiology
  • Diagnostic Imaging* / statistics & numerical data
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Observer Variation
  • Prognosis
  • Retrospective Studies
  • Sensitivity and Specificity