Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol

Am J Obstet Gynecol. 1996 Mar;174(3):958-65. doi: 10.1016/s0002-9378(96)70333-2.


Objective: Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors.

Study design: Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up.

Results: Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 micrograms/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 microg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, alpha-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and alpha-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimullerian hormone, beta-inhibin, and estradiol were normal in most cases.

Conclusion: Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Mullerian Hormone
  • Biomarkers, Tumor / blood*
  • Estradiol / blood*
  • Female
  • Follow-Up Studies
  • Glycoproteins*
  • Granulosa Cell Tumor / blood
  • Granulosa Cell Tumor / diagnosis*
  • Growth Inhibitors / blood*
  • Humans
  • Inhibins*
  • Middle Aged
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / diagnosis*
  • Peptides / blood*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Testicular Hormones / blood*


  • Biomarkers, Tumor
  • Glycoproteins
  • Growth Inhibitors
  • Peptides
  • Testicular Hormones
  • inhibin-alpha subunit
  • Estradiol
  • Inhibins
  • Anti-Mullerian Hormone