Frostbite of the face after recreational misuse of nitrous oxide

Burns. 1996 Mar;22(2):152-3. doi: 10.1016/0305-4179(95)00090-9.


Exposure of the skin to nitrous oxide, a liquified gas stored under pressure in a cylinder, can occur in anaesthesiologists and in those involved in recreational misuse of the gas. A case is reported of a man who presented to the emergency department after sniffing nitrous oxide and sustaining frostbite injury to his left cheek. Conservative management of this injury allowed spontaneous separation of the necrotic tissue and healing of the granulating wound by contraction.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Facial Injuries / chemically induced*
  • Facial Injuries / therapy
  • Frostbite / chemically induced*
  • Humans
  • Male
  • Middle Aged
  • Nitrous Oxide / adverse effects*
  • Substance-Related Disorders / complications*


  • Nitrous Oxide