Balo's concentric sclerosis. Report of two patients with magnetic resonance imaging follow-up

J Neuroimaging. 1996 Apr;6(2):98-103. doi: 10.1111/jon19966298.


Balo's concentric sclerosis was diagnosed antemortem in 2 patients, by magnetic resonance (MR) imaging showing striking concentric alternating rings in 1 patient and by characteristic histopathological features in the other. The course of the lesions and the concentric pattern were followed by MR imaging for 3 years and 18 months, respectively. One patient demonstrated spontaneous remission that has not been reported in Balo's disease. Balo's disease may not have a fulminant course as described in the past and the MR appearance of the chronic lesion may resemble that of a chronic multiple sclerosis plaque.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Diseases / diagnosis
  • Brain Diseases / pathology
  • Contrast Media
  • Diffuse Cerebral Sclerosis of Schilder / diagnosis*
  • Diffuse Cerebral Sclerosis of Schilder / pathology
  • Female
  • Follow-Up Studies
  • Gadolinium
  • Gadolinium DTPA
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / pathology
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Remission, Spontaneous


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA