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. 1996 Jun 5;103(2):183-9.
doi: 10.1016/0304-3835(96)04212-7.

Ascorbic Acid (Vitamin C) Improves the Antineoplastic Activity of Doxorubicin, Cisplatin, and Paclitaxel in Human Breast Carcinoma Cells in Vitro

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Ascorbic Acid (Vitamin C) Improves the Antineoplastic Activity of Doxorubicin, Cisplatin, and Paclitaxel in Human Breast Carcinoma Cells in Vitro

C M Kurbacher et al. Cancer Lett. .

Abstract

Utilizing a microplate ATP bioluminescence assay, two human breast carcinoma cell lines, MCF-7 and MDA-MB-231, were tested against doxorubicin (DOX), cisplatin (DDP), and paclitaxel (Tx) alone and in combination with ascorbic acid (Vit C). In both cell lines, Vit C exhibited cytotoxic activity at high concentrations (i.e. 10(2)-10(3) microM). Both cell lines also were resistant to DOX. MCF-7 was found to be DDP-resistant, MDA-MB-231 was moderately sensitive to DDP. Both cell lines were strongly sensitive to Tx. Vit C both at non-cytotoxic (1 microM) and moderately cytotoxic concentrations (10(2) microM) improved the cytotoxicity of DOX, DDP, and Tx significantly. Combination effects between Vit C and DDP or Tx were partly synergistic and partly additive or subadditive whereas a consistent synergism was found between Vit C and DOX. The mechanisms by which Vit C potentiates the cytostatics studied are yet unclear and should be evaluated further.

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