Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer

Gastrointest Endosc. 1996 Feb;43(2 Pt 1):111-6. doi: 10.1016/s0016-5107(06)80110-0.


Background: The aim of this study was to assess the factors that may cause failure of endoscopic injection in patients bleeding from a duodenal ulcer.

Methods: One hundred twenty patients admitted for a bleeding duodenal ulcer with active arterial hemorrhage or a nonbleeding visible vessel were included.

Results: Endoscopic injection was not feasible in 14 of 120 (11.6%) patients because of inaccessibility or massive hemorrhage. The remaining 106 patients underwent endoscopic therapy by injection of adrenaline and polidocanol. The efficacy (achievement of definitive hemostasis) of endoscopy therapy was 83% (88 of 106). Univariate analysis showed that failure of endoscopic injection was related to age, presence of shock, ulcer size greater than 2 cm, and hemoglobin level. Multivariate analysis showed that ulcer size greater than 2 cm (p = 0.005) and the presence of shock (p = 0.03) were factors predictive of endoscopic treatment failure. Failure to achieve hemostasis (p < 0.001) and poor physical status measured by American Society of Anesthesiology classification (p = 0.02) were significantly related to mortality.

Conclusions: Ulcer size and severity of hemorrhage are predictive of endoscopic injection failure in patients bleeding from high-risk duodenal ulcers. Survival is determined by clinical status and associated diseases.

MeSH terms

  • Aged
  • Duodenal Ulcer / complications
  • Duodenal Ulcer / therapy*
  • Epinephrine / therapeutic use
  • Female
  • Hemostasis, Endoscopic*
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Peptic Ulcer Hemorrhage / etiology
  • Peptic Ulcer Hemorrhage / mortality
  • Peptic Ulcer Hemorrhage / therapy*
  • Polidocanol
  • Polyethylene Glycols / therapeutic use
  • Retrospective Studies
  • Sclerosing Solutions / therapeutic use
  • Survival Rate
  • Treatment Failure
  • Vasoconstrictor Agents / therapeutic use


  • Sclerosing Solutions
  • Vasoconstrictor Agents
  • Polidocanol
  • Polyethylene Glycols
  • Epinephrine