Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging

J Pediatr. 1996 Feb;128(2):296-301. doi: 10.1016/s0022-3476(96)70414-6.


Objective: To determine the reversibility of the loss of brain parenchyma and ventricular enlargement in patients with anorexia nervosa after refeeding.

Study design: Quantitative magnetic resonance imaging was performed on three groups of subjects: (1) 12 female adolescents hospitalized with anorexia nervosa, (2) the same 12 patients after nutritional rehabilitation, a mean of 11.1 months later, and (3) 12 healthy age-matched control subjects. Sixty-four contiguous coronal magnetic resonance images, 3.1 mm thick, were obtained. With a computerized morphometry system, lateral and third ventricular volumes were measured by a single observer unaware of the status of the patient.

Results: On admission, patients were malnourished and had lost an average of 11.7 kg (body mass index, 14.3 +/- 2.0 kg/m2). After refeeding, they gained an average of 9.7 kg (body mass index, 17.9 +/- 1.5 kg/m2). Total ventricular volume decreased from 17.1 +/- 5.5 cm3 on admission to 12.4 +/- 3.0 cm3 after refeeding (p < 0.01) and returned to the normal range. The degree of enlargement of the third ventricle was greater than that of the lateral ventricles. There was a significant inverse relationship between body mass index and total ventricular volume (r = -0.63; p < 0.05).

Conclusion: In patients with anorexia nervosa, cerebral ventricular enlargement correlates with the degree of malnutrition and is reversible with weight gain during long-term follow-up.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Anorexia Nervosa / complications
  • Anorexia Nervosa / drug therapy*
  • Anorexia Nervosa / pathology
  • Body Mass Index
  • Body Weight
  • Cerebral Ventricles / anatomy & histology*
  • Cerebral Ventricles / pathology
  • Child
  • Drug Therapy, Combination
  • Female
  • Hospitalization
  • Humans
  • Magnetic Resonance Imaging*
  • Nutrition Disorders / complications
  • Penicillamine / therapeutic use
  • Sulfates / therapeutic use
  • Trientine / therapeutic use
  • Zinc Compounds / therapeutic use
  • Zinc Sulfate


  • Sulfates
  • Zinc Compounds
  • Zinc Sulfate
  • Penicillamine
  • Trientine